› 2onj

X-ray diffraction
3.4Å resolution

Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP

Released:
DOI: 10.2210/pdb2onj/pdb
PDB entry 2onj coloured by chain, front view.
PDB entry 2onj coloured by chain, side view.
PDB entry 2onj coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP.
Dawson RJ, Locher KP
FEBS Lett 581 935-8 (2007)
PMID: 17303126

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative multidrug export ATP-binding/permease protein SAV1866 Chains: A, B
Molecule details ›
Chains: A, B
Length: 578 amino acids
Theoretical weight: 64.93 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99T13 (Residues: 1-578; Coverage: 100%)
Gene name: SAV1866
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NA 4 x NA
Ligand ANP 2 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 160.961Å b: 104.447Å c: 181.391Å
α: 90° β: 98.23° γ: 90°
R-values:
R R work R free
0.254 0.254 0.278
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Structure, function, and evolution of bacterial ATP-binding cassette systems.
Davidson et al. (2008)
51 more

50 mentions without citation

ABC transporters: the power to change.
Rees et al. (2009)
49 more