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Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma

X-ray diffraction
2.8Å resolution
PDB entry 2om9 coloured by chain, front view.
PDB entry 2om9 coloured by chain, side view.
PDB entry 2om9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: monomeric
Accessible surface area: 13925.62 Å2
Buried surface area: 1292.51 Å2
Dissociation area: 178.81 Å2
Dissociation energy (ΔGdiss): -2.8 kcal/mol
Dissociation entropy (TΔSdiss): 4.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368
Assembly 2
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: monomeric
Accessible surface area: 13590.95 Å2
Buried surface area: 1300.74 Å2
Dissociation area: 181.01 Å2
Dissociation energy (ΔGdiss): -4.92 kcal/mol
Dissociation entropy (TΔSdiss): 4.64 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368
Assembly 3
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: monomeric
Accessible surface area: 13657.59 Å2
Buried surface area: 1571.94 Å2
Dissociation area: 314.76 Å2
Dissociation energy (ΔGdiss): -2.17 kcal/mol
Dissociation entropy (TΔSdiss): 4.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368
Assembly 4
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: monomeric
Accessible surface area: 13314.64 Å2
Buried surface area: 1572.31 Å2
Dissociation area: 307.8 Å2
Dissociation energy (ΔGdiss): -3.05 kcal/mol
Dissociation entropy (TΔSdiss): 4.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368

Macromolecules

Peroxisome proliferator-activated receptor gamma
Chains: A, B, C, D
Length: 278 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Peroxisome proliferator-activated receptor gamma in PDB entry 2om9, assembly 1, front view.
Peroxisome proliferator-activated receptor gamma in PDB entry 2om9, assembly 1, side view.
Peroxisome proliferator-activated receptor gamma in PDB entry 2om9, assembly 1, top view.
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