Structure analysis

Mycoplasma arthritidis-derived mitogen complexed with class II MHC molecule HLA-DR1/HA complex in the presence of EDTA

X-ray diffraction
3Å resolution
Assemblies composition:
hetero tetramer (preferred)
hetero 16-mer
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 28000 Å2
Buried surface area: 10200 Å2
Dissociation area: 1,500 Å2
Dissociation energy (ΔGdiss): 20 kcal/mol
Dissociation entropy (TΔSdiss): 9 kcal/mol
Interface energy (ΔGint): -57 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero tetramer
Accessible surface area: 28000 Å2
Buried surface area: 10100 Å2
Dissociation area: 1,500 Å2
Dissociation energy (ΔGdiss): 23 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -67 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero 16-mer
Accessible surface area: 56100 Å2
Buried surface area: 20100 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): -134 kcal/mol
Symmetry number: 2

Macromolecules

Chains: D, H
Length: 214 amino acids
Theoretical weight: 25.42 KDa
Source organism: Mycoplasma arthritidis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q48898 (Residues: 25-238; Coverage: 90%)
Pfam: Mycoplasma arthritidis-derived mitogen
InterPro:
CATH:
SCOP: Superantigen MAM

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Chains: C, G
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/Taiwan/0095/1996(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: Q91LS8 (Residues: 260-272; Coverage: 5%)
Gene name: HA

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