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Crystal structure of IRAK4 kinase domain complexed with staurosporine

X-ray diffraction
2.4Å resolution
PDB entry 2oic coloured by chain, front view.
PDB entry 2oic coloured by chain, side view.
PDB entry 2oic coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-1 receptor-associated kinase 4
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Multimeric state: monomeric
Accessible surface area: 13439.03 Å2
Buried surface area: 894.58 Å2
Dissociation area: 447.29 Å2
Dissociation energy (ΔGdiss): -3.62 kcal/mol
Dissociation entropy (TΔSdiss): 4.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 2
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Assembly Name: Interleukin-1 receptor-associated kinase 4
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Multimeric state: monomeric
Accessible surface area: 13461.36 Å2
Buried surface area: 876.91 Å2
Dissociation area: 438.46 Å2
Dissociation energy (ΔGdiss): -3.79 kcal/mol
Dissociation entropy (TΔSdiss): 4.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 3
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Assembly Name: Interleukin-1 receptor-associated kinase 4
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Multimeric state: monomeric
Accessible surface area: 14396.54 Å2
Buried surface area: 881.82 Å2
Dissociation area: 440.91 Å2
Dissociation energy (ΔGdiss): -3.36 kcal/mol
Dissociation entropy (TΔSdiss): 4.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 4
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Assembly Name: Interleukin-1 receptor-associated kinase 4
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Multimeric state: monomeric
Accessible surface area: 13831.18 Å2
Buried surface area: 890.36 Å2
Dissociation area: 445.18 Å2
Dissociation energy (ΔGdiss): -3.12 kcal/mol
Dissociation entropy (TΔSdiss): 4.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669

Macromolecules

Interleukin-1 receptor-associated kinase 4
Chains: A, B, C, D
Length: 301 amino acids
Theoretical weight: 33.96 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9NWZ3 (Residues: 160-460; Coverage: 65%)
Gene name: IRAK4
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Interleukin-1 receptor-associated kinase 4 in PDB entry 2oic, assembly 1, front view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 2oic, assembly 1, side view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 2oic, assembly 1, top view.
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