PDBe 2oh0

X-ray diffraction
2.2Å resolution

Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inhibitory peptide Chain: I
Molecule details ›
Chain: I
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Synthetic construct
Expression system: Not provided
cAMP-dependent protein kinase catalytic subunit alpha Chain: E
Molecule details ›
Chain: E
Length: 351 amino acids
Theoretical weight: 40.68 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00517 (Residues: 1-351; Coverage: 100%)
Gene name: PRKACA
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 72.492Å b: 74.854Å c: 80.165Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.273 0.32
Expression systems:
  • Not provided
  • Escherichia coli