PDBe 2og8

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chains: A, B
Molecule details ›
Chains: A, B
Length: 265 amino acids
Theoretical weight: 30.52 KDa
Source organism: Homo sapiens
Expression system: Insect Cell
UniProt:
  • Canonical: P06239 (Residues: 237-499; Coverage: 52%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 62.69Å b: 80.07Å c: 132.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.247 0.3
Expression system: Insect Cell