PDBe 2ofv

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase Lck Chains: A, B
Molecule details ›
Chains: A, B
Length: 277 amino acids
Theoretical weight: 32.06 KDa
Source organism: Homo sapiens
Expression system: Insect Cell
  • Canonical: P06239 (Residues: 232-498; Coverage: 53%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 142.66Å b: 66.89Å c: 78.51Å
α: 90° β: 112° γ: 90°
R R work R free
0.274 0.274 0.301
Expression system: Insect Cell