PDBe 2of2

X-ray diffraction
2Å resolution

crystal structure of furanopyrimidine 8 bound to lck

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 271 amino acids
Theoretical weight: 31.35 KDa
Source organism: Homo sapiens
Expression system: Insect cell
UniProt:
  • Canonical: P06239 (Residues: 231-501; Coverage: 53%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 42.2Å b: 74.3Å c: 92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.26 0.26
Expression system: Insect cell