PDBe 2obv

X-ray diffraction
2.05Å resolution

Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product

Source organism: Homo sapiens
Entry authors: Pilka ES, Shafqat N, Kavanagh KL, Cooper C, Hozjan V, Turnbull A, von Delft F, Arrowsmith CH, Edwards A, Weigelt J, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
S-adenosylmethionine synthase isoform type-1 Chain: A
Molecule details ›
Chain: A
Length: 384 amino acids
Theoretical weight: 42.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q00266 (Residues: 16-395; Coverage: 96%)
Gene names: AMS1, MAT1A, MATA1
Sequence domains:
Structure domains: GMP Synthetase; Chain A, domain 3

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: I222
Unit cell:
a: 66.404Å b: 95.016Å c: 115.773Å
α: 90° β: 90° γ: 90°
R R work R free
0.141 0.139 0.183
Expression system: Escherichia coli