PDBe 2obj

X-ray diffraction
2.5Å resolution

Crystal structure of human PIM-1 Kinase in complex with inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 333 amino acids
Theoretical weight: 37.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 92-404; Coverage: 78%)
  • Best match: P11309-2 (Residues: 1-313)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P65
Unit cell:
a: 97.264Å b: 97.264Å c: 80.827Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.205 0.246
Expression system: Escherichia coli