Structure analysis

Structure of SHH variant of "Bergerac" chimera of spectrin SH3

X-ray diffraction
1.9Å resolution
Source organism: Gallus gallus
Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: monomeric
Accessible surface area: 4600 Å2
Buried surface area: 250 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 9 kcal/mol
Dissociation entropy (TΔSdiss): -1 kcal/mol
Interface energy (ΔGint): -17 kcal/mol
Symmetry number: 1
Assembly 2 (preferred)
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Multimeric state: monomeric
Accessible surface area: 4700 Å2
Buried surface area: 500 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 8 kcal/mol
Dissociation entropy (TΔSdiss): -1 kcal/mol
Interface energy (ΔGint): -33 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: monomeric
Accessible surface area: 4800 Å2
Buried surface area: 100 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 9 kcal/mol
Dissociation entropy (TΔSdiss): -1 kcal/mol
Interface energy (ΔGint): -8 kcal/mol
Symmetry number: 1
Assembly 4
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Multimeric state: monomeric
Accessible surface area: 4600 Å2
Buried surface area: 250 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 8 kcal/mol
Dissociation entropy (TΔSdiss): -1 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 1
Assembly 5
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Multimeric state: homo tetramer
Accessible surface area: 4600 Å2
Buried surface area: 250 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 8 kcal/mol
Dissociation entropy (TΔSdiss): -1 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B, C, D
Length: 65 amino acids
Theoretical weight: 7.6 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07751 (Residues: 969-1009, 1010-1011, 1012-1025; Coverage: 2%)
Gene names: SPTA2, SPTAN1
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains

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