› 2o9j

X-ray diffraction
2.65Å resolution

Crystal structure of calcium atpase with bound magnesium fluoride and cyclopiazonic acid

Released:
DOI: 10.2210/pdb2o9j/pdb
PDB entry 2o9j coloured by chain, front view.
PDB entry 2o9j coloured by chain, side view.
PDB entry 2o9j coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
The molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pump.
Moncoq K, Trieber CA, Young HS
J Biol Chem 282 9748-9757 (2007)
PMID: 17259168

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

4 bound ligands:
Ligand MG 1 x MG
Ligand NA 1 x NA
Ligand MF4 1 x MF4
Ligand CZA 1 x CZA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1
Spacegroup: C2
Unit cell:
a: 175.383Å b: 69.875Å c: 143.411Å
α: 90° β: 107.1° γ: 90°
R-values:
R R work R free
0.248 0.246 0.287

Quick links

Citations

18 review citations

Calcium pumps in health and disease.
Brini et al. (2009)
17 more

5 mentions without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)
4 more