Articles - 2o6x mentioned but not cited (23)
- Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. J Biol Chem 283 9896-9908 (2008)
- Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica. Robinson MW, Corvo I, Jones PM, George AM, Padula MP, To J, Cancela M, Rinaldi G, Tort JF, Roche L, Dalton JP. PLoS Negl Trop Dis 5 e1012 (2011)
- A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. J Biol Chem 285 18516-18527 (2010)
- Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis. Opron K, Xia K, Wei GW. J Chem Phys 140 234105 (2014)
- Lessons from high-throughput protein crystallization screening: 10 years of practical experience. Luft JR, Snell EH, Detitta GT. Expert Opin Drug Discov 6 465-480 (2011)
- Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B. Sripa J, Laha T, To J, Brindley PJ, Sripa B, Kaewkes S, Dalton JP, Robinson MW. Cell Microbiol 12 781-795 (2010)
- Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES. Smith D, Tikhonova IG, Jewhurst HL, Drysdale OC, Dvořák J, Robinson MW, Cwiklinski K, Dalton JP. J Biol Chem 291 19220-19234 (2016)
- Anthelmintic Potential of Thymoquinone and Curcumin on Fasciola gigantica. Ullah R, Rehman A, Zafeer MF, Rehman L, Khan YA, Khan MA, Khan SN, Khan AU, Abidi SM. PLoS One 12 e0171267 (2017)
- The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease. Tang Z, Shang M, Chen T, Ren P, Sun H, Qu H, Lin Z, Zhou L, Yu J, Jiang H, Zhou X, Li X, Huang Y, Xu J, Yu X. Parasit Vectors 9 648 (2016)
- Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches. Hernández Alvarez L, Naranjo Feliciano D, Hernández González JE, Soares RO, Barreto Gomes DE, Pascutti PG. PLoS Negl Trop Dis 9 e0003759 (2015)
- Transcriptome of Sphaerospora molnari (Cnidaria, Myxosporea) blood stages provides proteolytic arsenal as potential therapeutic targets against sphaerosporosis in common carp. Hartigan A, Kosakyan A, Pecková H, Eszterbauer E, Holzer AS. BMC Genomics 21 404 (2020)
- An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica. Smith D, Cwiklinski K, Jewhurst H, Tikhonova IG, Dalton JP. Sci Rep 10 20657 (2020)
- Blind prediction of protein B-factor and flexibility. Bramer D, Wei GW. J Chem Phys 149 134107 (2018)
- Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. Front Mol Biosci 5 40 (2018)
- Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design. Musyoka TM, Njuguna JN, Tastan Bishop Ö. Malar J 18 159 (2019)
- Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach. Buffoni L, Garza-Cuartero L, Pérez-Caballero R, Zafra R, Javier Martínez-Moreno F, Molina-Hernández V, Pérez J, Martínez-Moreno Á, Martínez-Moreno Á, Mulcahy G. Parasit Vectors 13 390 (2020)
- Molecular cloning and anti-invasive activity of cathepsin L propeptide-like protein from Calotropis procera R. Br. against cancer cells. Kwon CW, Yang H, Yeo S, Park KM, Jeong AJ, Lee KW, Ye SK, Chang PS. J Enzyme Inhib Med Chem 33 657-664 (2018)
- Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes. Johé P, Jaenicke E, Neuweiler H, Schirmeister T, Kersten C, Hellmich UA. J Biol Chem 296 100565 (2021)
- Fasciola hepatica Cathepsin L Zymogens: Immuno-Proteomic Evidence for Highly Immunogenic Zymogen-Specific Conformational Epitopes to Support Diagnostics Development. Collett CF, Phillips HC, Fisher M, Smith S, Fenn C, Goodwin P, Morphew RM, Brophy PM. J Proteome Res 21 1997-2010 (2022)
- Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition. Pritsch IC, Tikhonova IG, Jewhurst HL, Drysdale O, Cwiklinski K, Molento MB, Dalton JP, Verissimo CM. BMC Mol Cell Biol 21 90 (2020)
- Atom-specific persistent homology and its application to protein flexibility analysis. Bramer D, Wei GW. Comput Math Biophys 8 1-35 (2020)
- High relatedness of bioinformatic data and realistic experimental works on the potentials of Fasciola hepatica and F. gigantica cathepsin L1 as a diagnostic and vaccine antigen. Fereig RM, Metwally S, El-Alfy ES, Abdelbaky HH, Shanab O, Omar MA, Alsayeqh AF. Front Public Health 10 1054502 (2022)
- Proteases as Therapeutic Targets Against the Parasitic Cnidarian Ceratonova shasta: Characterization of Molecules Key to Parasite Virulence In Salmonid Hosts. Alama-Bermejo G, Bartošová-Sojková P, Atkinson SD, Holzer AS, Bartholomew JL. Front Cell Infect Microbiol 11 804864 (2021)
Reviews citing this publication (7)
- Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets. Verma S, Dixit R, Pandey KC. Front Pharmacol 7 107 (2016)
- Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy? Fairweather I. Vet Parasitol 180 133-143 (2011)
- Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective. McVeigh P, Maule AG, Dalton JP, Robinson MW. Microbes Infect 14 301-310 (2012)
- Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites. Pearson MS, Ranjit N, Loukas A. Biol Chem 391 901-911 (2010)
- Functional genes and proteins of Clonorchis sinensis. Kim TI, Na BK, Hong SJ. Korean J Parasitol 47 Suppl S59-68 (2009)
- Trematode Proteomics: Recent Advances and Future Directions. Bennett APS, Robinson MW. Pathogens 10 348 (2021)
- Structure determinants defining the specificity of papain-like cysteine proteases. Petushkova AI, Savvateeva LV, Zamyatnin AA. Comput Struct Biotechnol J 20 6552-6569 (2022)
Articles citing this publication (45)
- An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host. Robinson MW, Menon R, Donnelly SM, Dalton JP, Ranganathan S. Mol Cell Proteomics 8 1891-1907 (2009)
- The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis. Cwiklinski K, de la Torre-Escudero E, Trelis M, Bernal D, Dufresne PJ, Brennan GP, O'Neill S, Tort J, Paterson S, Marcilla A, Dalton JP, Robinson MW. Mol Cell Proteomics 14 3258-3273 (2015)
- Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3. Donnelly S, O'Neill SM, Stack CM, Robinson MW, Turnbull L, Whitchurch C, Dalton JP. J Biol Chem 285 3383-3392 (2010)
- A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides. Robinson MW, Donnelly S, Hutchinson AT, To J, Taylor NL, Norton RS, Perugini MA, Dalton JP. PLoS Pathog 7 e1002042 (2011)
- Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses. Dowling DJ, Hamilton CM, Donnelly S, La Course J, Brophy PM, Dalton J, O'Neill SM. Infect Immun 78 793-801 (2010)
- Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors. Robinson MW, Tort JF, Lowther J, Donnelly SM, Wong E, Xu W, Stack CM, Padula M, Herbert B, Dalton JP. Mol Cell Proteomics 7 1111-1123 (2008)
- Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. J Med Chem 52 852-857 (2009)
- Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis. Yoo WG, Kim DW, Ju JW, Cho PY, Kim TI, Cho SH, Choi SH, Park HS, Kim TS, Hong SJ. PLoS Negl Trop Dis 5 e1208 (2011)
- A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase. Robinson MW, Alvarado R, To J, Hutchinson AT, Dowdell SN, Lund M, Turnbull L, Whitchurch CB, O'Brien BA, Dalton JP, Donnelly S. FASEB J 26 4614-4627 (2012)
- A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica. Cancela M, Acosta D, Rinaldi G, Silva E, Durán R, Roche L, Zaha A, Carmona C, Tort JF. Biochimie 90 1461-1475 (2008)
- The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease. Lowther J, Robinson MW, Donnelly SM, Xu W, Stack CM, Matthews JM, Dalton JP. PLoS Negl Trop Dis 3 e369 (2009)
- Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini. Pinlaor P, Kaewpitoon N, Laha T, Sripa B, Kaewkes S, Morales ME, Mann VH, Parriott SK, Suttiprapa S, Robinson MW, To J, Dalton JP, Loukas A, Brindley PJ. PLoS Negl Trop Dis 3 e398 (2009)
- The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen. Corvo I, Cancela M, Cappetta M, Pi-Denis N, Tort JF, Roche L. Mol Biochem Parasitol 167 41-47 (2009)
- Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity. El Ridi R, Tallima H, Selim S, Donnelly S, Cotton S, Gonzales Santana B, Dalton JP. PLoS One 9 e85401 (2014)
- SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. PLoS Negl Trop Dis 3 e449 (2009)
- Molecular and immunological characterization of Fasciola antigens recognized by the MM3 monoclonal antibody. Muiño L, Perteguer MJ, Gárate T, Martínez-Sernández V, Beltrán A, Romarís F, Mezo M, González-Warleta M, Ubeira FM. Mol Biochem Parasitol 179 80-90 (2011)
- A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites. Beckham SA, Piedrafita D, Phillips CI, Samarawickrema N, Law RH, Smooker PM, Quinsey NS, Irving JA, Greenwood D, Verhelst SH, Bogyo M, Turk B, Coetzer TH, Wijeyewickrema LC, Spithill TW, Pike RN. Int J Biochem Cell Biol 41 1601-1612 (2009)
- Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S. Parasit Vectors 3 63 (2010)
- Proteomic analysis of in vitro newly excysted juveniles from Fasciola hepatica. Hernández-González A, Valero ML, del Pino MS, Oleaga A, Siles-Lucas M. Mol Biochem Parasitol 172 121-128 (2010)
- Towards delineating functions within the fasciola secreted cathepsin l protease family by integrating in vivo based sub-proteomics and phylogenetics. Morphew RM, Wright HA, Lacourse EJ, Porter J, Barrett J, Woods DJ, Brophy PM. PLoS Negl Trop Dis 5 e937 (2011)
- Molecular cloning, characterization and functional analysis of a novel juvenile-specific cathepsin L of Fasciola gigantica. Sansri V, Changklungmoa N, Chaichanasak P, Sobhon P, Meemon K. Acta Trop 128 76-84 (2013)
- Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity. Suttiprapa S, Mulvenna J, Huong NT, Pearson MS, Brindley PJ, Laha T, Wongkham S, Kaewkes S, Sripa B, Loukas A. Int J Biochem Cell Biol 41 1148-1156 (2009)
- Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. PLoS Negl Trop Dis 7 e2269 (2013)
- Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. Biochimie 122 99-109 (2016)
- Novel antimalarial drug targets: hope for new antimalarial drugs. Alam A, Goyal M, Iqbal MS, Pal C, Dey S, Bindu S, Maity P, Bandyopadhyay U. Expert Rev Clin Pharmacol 2 469-489 (2009)
- Protection and antibody isotype responses against Fasciola hepatica with specific antibody to pIII-displayed peptide mimotopes of cathepsin L1 in sheep. Villa-Mancera A, Méndez-Mendoza M. Vet J 194 108-112 (2012)
- Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp. Jedličková L, Dvořáková H, Dvořák J, Kašný M, Ulrychová L, Vorel J, Žárský V, Mikeš L. Parasit Vectors 11 142 (2018)
- Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen. Groeme R, Airouche S, Kopečný D, Jaekel J, Savko M, Berjont N, Bussieres L, Le Mignon M, Jagic F, Zieglmayer P, Baron-Bodo V, Bordas-Le Floch V, Mascarell L, Briozzo P, Moingeon P. J Biol Chem 291 13076-13087 (2016)
- 41.5-kDa Cathepsin L protease from Clonorchis sinensis: expression, characterization, and serological reactivity of one excretory-secretory antigen. Li Y, Huang Y, Hu X, Liu X, Ma C, Zhao J, Wu Z, Xu J, Yu X. Parasitol Res 111 673-680 (2012)
- Characterization and differential expression of cathepsin L3 alleles from Fasciola hepatica. Zawistowska-Deniziak A, Wasyl K, Norbury LJ, Wesołowska A, Bień J, Grodzik M, Wiśniewski M, Bąska P, Wędrychowicz H. Mol Biochem Parasitol 190 27-37 (2013)
- Comparative transcriptome profiling approach to glean virulence and immunomodulation-related genes of Fasciola hepatica. Haçarız O, Akgün M, Kavak P, Yüksel B, Sağıroğlu MŞ. BMC Genomics 16 366 (2015)
- MISS-Prot: web server for self/non-self discrimination of protein residue networks in parasites; theory and experiments in Fasciola peptides and Anisakis allergens. González-Díaz H, Muíño L, Anadón AM, Romaris F, Prado-Prado FJ, Munteanu CR, Dorado J, Sierra AP, Mezo M, González-Warleta M, Gárate T, Ubeira FM. Mol Biosyst 7 1938-1955 (2011)
- Mechanisms of liver fibrosis associated with experimental Fasciola hepatica infection: roles of Fas2 proteinase and hepatic stellate cell activation. Marcos LA, Terashima A, Yi P, Andrade R, Cubero FJ, Albanis E, Gotuzzo E, Espinoza JR, Friedman SL. J Parasitol 97 82-87 (2011)
- Cathepsin L3 From Fasciola hepatica Induces NLRP3 Inflammasome Alternative Activation in Murine Dendritic Cells. Celias DP, Corvo I, Silvane L, Tort JF, Chiapello LS, Fresno M, Arranz A, Motrán CC, Cervi L. Front Immunol 10 552 (2019)
- Adult Opisthorchis felineus major protein fractions deduced from transcripts: comparison with liver flukes Opisthorchis viverrini and Clonorchis sinensis. Pomaznoy M, Tatkov S, Katokhin A, Afonnikov D, Babenko V, Furman D, Brusentsov I, Belavin P, Najakshin A, Guselnikov S, Vasiliev G, Sivkov A, Prokhortchouk E, Skryabin K, Mordvinov V. Exp Parasitol 135 297-306 (2013)
- Cathepsin L in the orange-spotted grouper, Epinephelus coioides: molecular cloning and gene expression after a Vibrio anguillarum challenge. Liang JZ, Rao YZ, Lun ZR, Yang TB. Fish Physiol Biochem 38 1795-1806 (2012)
- Differences in the antibody response to adult Fasciola hepatica excretory/secretory products in experimentally and naturally infected cattle and sheep. Walsh TR, Ainsworth S, Armstrong S, Hodgkinson J, Williams D. Vet Parasitol 289 109321 (2021)
- The Zoonotic Helminth Parasite Fasciola hepatica: Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles (NEJ). Barbour T, Cwiklinski K, Lalor R, Dalton JP, De Marco Verissimo C. Animals (Basel) 11 3495 (2021)
- Molecular characterization and determination of the biochemical properties of cathepsin L of Trichinella spiralis. Liu RD, Meng XY, Li CL, Long SR, Cui J, Wang ZQ. Vet Res 53 48 (2022)
- Fasciola hepatica Gastrodermal Cells Selectively Release Extracellular Vesicles via a Novel Atypical Secretory Mechanism. Bennett APS, de la Torre-Escudero E, Dermott SSE, Threadgold LT, Hanna REB, Robinson MW. Int J Mol Sci 23 5525 (2022)
- Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L. (Coleoptera: Curculionidae). Ben-Mahmoud S, Ramos JE, Shatters RG, Rougé P, Powell CA, Smagghe G, Borovsky D. J Insect Physiol 72 1-13 (2015)
- Exploiting Comparative Omics to Understand the Pathogenic and Virulence-Associated Protease: Anti-Protease Relationships in the Zoonotic Parasites Fasciola hepatica and Fasciola gigantica. Cwiklinski K, Dalton JP. Genes (Basel) 13 1854 (2022)
- Exploring Evolutionary Relationships within Neodermata Using Putative Orthologous Groups of Proteins, with Emphasis on Peptidases. Caña-Bozada V, Robinson MW, Hernández-Mena DI, Morales-Serna FN. Trop Med Infect Dis 8 59 (2023)
- An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily. Buša M, Matoušková Z, Bartošová-Sojková P, Pachl P, Řezáčová P, Eichenberger RM, Deplazes P, Horn M, Štefanić S, Mareš M. J Biol Chem 299 102970 (2023)
- Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates. Kolla VK, Prasad R, Sayyad Z, Atul, Shah AY, Allanki AD, Navale R, Singhal N, Tanneru N, Sudhakar R, Venkatesan V, Deshmukh MV, Sijwali PS. Mol Biochem Parasitol 202 11-22 (2015)