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Crystal Structure of ProCathepsin L1 from Fasciola hepatica

Source organism: Fasciola hepatica
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis involved in protein catabolic process
Cellular component: lysosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin L-like proteinase
The deposited structure of PDB entry 2o6x contains 1 copy of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin L-like proteinase. Showing 1 copy in chain A.

PF08246
Domain description: Cathepsin propeptide inhibitor domain (I29)
Occurring in:
  1. Cathepsin L-like proteinase
The deposited structure of PDB entry 2o6x contains 1 copy of Pfam domain PF08246 (Cathepsin propeptide inhibitor domain (I29)) in Cathepsin L-like proteinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin L-like proteinase
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin L-like proteinase
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin L-like proteinase
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Cathepsin L-like proteinase
IPR013201
Domain description: Cathepsin propeptide inhibitor domain (I29)
Occurring in:
  1. Cathepsin L-like proteinase
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin L-like proteinase
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin L-like proteinase

Structure domain

CATH CATH domain
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cathepsin L-like proteinase
The deposited structure of PDB entry 2o6x contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cathepsin L-like proteinase. Showing 1 copy in chain A.

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