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Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH

X-ray diffraction
2.2Å resolution
PDB entry 2o6v coloured by chain, front view.
PDB entry 2o6v coloured by chain, side view.
PDB entry 2o6v coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ubiquitin
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Multimeric state: hetero tetramer
Accessible surface area: 14404.68 Å2
Buried surface area: 5567.27 Å2
Dissociation area: 2,332.49 Å2
Dissociation energy (ΔGdiss): -2.62 kcal/mol
Dissociation entropy (TΔSdiss): 32.22 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-143329
Assembly 2
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Assembly Name: Ubiquitin
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Multimeric state: hetero tetramer
Accessible surface area: 14038.19 Å2
Buried surface area: 4548.97 Å2
Dissociation area: 2,196.93 Å2
Dissociation energy (ΔGdiss): -3.29 kcal/mol
Dissociation entropy (TΔSdiss): 32.07 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-143329
Assembly 3
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Assembly Name: Ubiquitin
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Multimeric state: hetero tetramer
Accessible surface area: 13561.36 Å2
Buried surface area: 6410.6 Å2
Dissociation area: 2,754.66 Å2
Dissociation energy (ΔGdiss): 11.47 kcal/mol
Dissociation entropy (TΔSdiss): 32.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-143329

Macromolecules

Ubiquitin
Chains: A, C, E, G
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG48 (Residues: 609-684; Coverage: 11%)
Gene name: UBC
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
SCOP: Ubiquitin-related
Ubiquitin in PDB entry 2o6v, assembly 1, front view.
Ubiquitin in PDB entry 2o6v, assembly 1, side view.
Ubiquitin in PDB entry 2o6v, assembly 1, top view.
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Ubiquitin
Chains: B, F
Length: 76 amino acids
Theoretical weight: 8.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG48 (Residues: 609-684; Coverage: 11%)
Gene name: UBC
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
SCOP: Ubiquitin-related
Ubiquitin in PDB entry 2o6v, assembly 1, front view.
Ubiquitin in PDB entry 2o6v, assembly 1, side view.
Ubiquitin in PDB entry 2o6v, assembly 1, top view.
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Ubiquitin
Chains: D, H
Length: 76 amino acids
Theoretical weight: 8.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG48 (Residues: 609-684; Coverage: 11%)
Gene name: UBC
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
SCOP: Ubiquitin-related
Ubiquitin in PDB entry 2o6v, assembly 1, front view.
Ubiquitin in PDB entry 2o6v, assembly 1, side view.
Ubiquitin in PDB entry 2o6v, assembly 1, top view.
Molecule details ›

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