PDBe 2o5k

X-ray diffraction
3.2Å resolution

Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 42.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P49841 (Residues: 29-393; Coverage: 87%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 70.94Å b: 72.632Å c: 81.795Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.24 0.309
Expression system: Escherichia coli BL21