PDBe 2o4u

X-ray diffraction
2Å resolution

Crystal structure of Mammalian Dimeric Dihydrodiol Dehydrogenase


Function and Biology Details

Reactions catalysed:
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH
D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Chain: X
Molecule details ›
Chain: X
Length: 334 amino acids
Theoretical weight: 36.48 KDa
Source organism: Macaca fascicularis
Expression system: Escherichia coli BL21
  • Canonical: Q9TQS6 (Residues: 1-334; Coverage: 100%)
Gene names: 2DD, DHDH
Sequence domains: Oxidoreductase family, NAD-binding Rossmann fold
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P6122
Unit cell:
a: 123.177Å b: 123.177Å c: 121.127Å
α: 90° β: 90° γ: 120°
R R work R free
0.176 0.161 0.193
Expression system: Escherichia coli BL21