PDBe 2o48

X-ray diffraction
2.59Å resolution

Crystal structure of Mammalian Dimeric Dihydrodiol Dehydrogenase

Released:

Function and Biology Details

Reactions catalysed:
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH
D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Chain: X
Molecule details ›
Chain: X
Length: 334 amino acids
Theoretical weight: 36.48 KDa
Source organism: Macaca fascicularis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9TQS6 (Residues: 1-334; Coverage: 100%)
Gene names: 2DD, DHDH
Sequence domains: Oxidoreductase family, NAD-binding Rossmann fold
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P6122
Unit cell:
a: 122.853Å b: 122.853Å c: 121.664Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.16 0.228
Expression system: Escherichia coli BL21