Function and Biology Details
Reaction catalysed:
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209626 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Botulinum neurotoxin type A
Molecule details ›
Chains: A, B
Length: 1295 amino acids
Theoretical weight: 149.48 KDa
Source organism: Clostridium botulinum
UniProt:
Sequence domains:
Length: 1295 amino acids
Theoretical weight: 149.48 KDa
Source organism: Clostridium botulinum
UniProt:
- Canonical:
P0DPI1 (Residues: 2-1296; Coverage: 100%)
Sequence domains:
- Clostridial neurotoxin zinc protease
- Clostridium neurotoxin, Translocation domain
- Clostridium neurotoxin, N-terminal receptor binding
- Clostridium neurotoxin, C-terminal receptor binding
