PDBe 2nz6

X-ray diffraction
2.3Å resolution

Crystal structure of the PTPRJ inactivating mutant C1239S

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase eta Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12913 (Residues: 1019-1311; Coverage: 23%)
Gene names: DEP1, PTPRJ
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 88.521Å b: 88.521Å c: 118.95Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.228
Expression system: Escherichia coli BL21(DE3)