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Crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline

X-ray diffraction
2.4Å resolution
PDB entry 2nz2 coloured by chain, front view.
PDB entry 2nz2 coloured by chain, side view.
PDB entry 2nz2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Argininosuccinate synthase
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Multimeric state: homo tetramer
Accessible surface area: 54923.06 Å2
Buried surface area: 26988.36 Å2
Dissociation area: 3,846.99 Å2
Dissociation energy (ΔGdiss): 67.58 kcal/mol
Dissociation entropy (TΔSdiss): 16.14 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-133741

Macromolecules

Argininosuccinate synthase
Chain: A
Length: 413 amino acids
Theoretical weight: 46.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00966 (Residues: 1-412; Coverage: 100%)
Gene names: ASS, ASS1
Pfam:
InterPro:
CATH:
Argininosuccinate synthase in PDB entry 2nz2, assembly 1, front view.
Argininosuccinate synthase in PDB entry 2nz2, assembly 1, side view.
Argininosuccinate synthase in PDB entry 2nz2, assembly 1, top view.
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