PDBe 2nz0

X-ray diffraction
3.2Å resolution

Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero octamer (preferred)
hetero 16-mer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kv channel-interacting protein 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 180 amino acids
Theoretical weight: 21.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZI2 (Residues: 49-227; Coverage: 79%)
Gene names: KCHIP1, KCNIP1, VABP
Sequence domains:
Structure domains: EF-hand
Potassium voltage-gated channel subfamily D member 3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 140 amino acids
Theoretical weight: 16.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UK17 (Residues: 6-145; Coverage: 21%)
Gene name: KCND3
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: I222
Unit cell:
a: 112.186Å b: 112.213Å c: 141.051Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.261 0.31
Expression system: Escherichia coli BL21(DE3)