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Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit

Source organisms:
Biochemical function: protein heterodimerization activity
Biological process: negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Cellular component: protein phosphatase type 2A complex

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EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02985
Domain description: HEAT repeat
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
The deposited structure of PDB entry 2nym contains 10 copies of Pfam domain PF02985 (HEAT repeat) in Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. Showing 5 copies in chain A.

PF00149
Domain description: Calcineurin-like phosphoesterase
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
The deposited structure of PDB entry 2nym contains 2 copies of Pfam domain PF00149 (Calcineurin-like phosphoesterase) in Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform. Showing 1 copy in chain C.

PF01603
Domain description: Protein phosphatase 2A regulatory B subunit (B56 family)
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
The deposited structure of PDB entry 2nym contains 2 copies of Pfam domain PF01603 (Protein phosphatase 2A regulatory B subunit (B56 family)) in Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR021133
Domain description: HEAT, type 2
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
IPR006186
Domain description: Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
IPR002554
Domain description: Protein phosphatase 2A, regulatory B subunit, B56
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
IPR029052
Domain description: Metallo-dependent phosphatase-like
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
  2. Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
  2. Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
IPR004843
Domain description: Calcineurin-like phosphoesterase domain, ApaH type
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
IPR047129
Domain description: Serine/Threonine protein phosphatase PP2A-like
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
IPR000357
Domain description: HEAT repeat
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Structure domains

CATH CATH domains
1.25.10.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Leucine-rich Repeat Variant
Homology: Leucine-rich Repeat Variant
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
  2. Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
The deposited structure of PDB entry 2nym contains 2 copies of CATH domain 1.25.10.10 (Leucine-rich Repeat Variant) in Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. Showing 1 copy in chain A.
The deposited structure of PDB entry 2nym contains 2 copies of CATH domain 1.25.10.10 (Leucine-rich Repeat Variant) in Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform. Showing 1 copy in chain B.
3.60.21.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Purple Acid Phosphatase; chain A, domain 2
Homology: Purple Acid Phosphatase; chain A, domain 2
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
The deposited structure of PDB entry 2nym contains 2 copies of CATH domain 3.60.21.10 (Purple Acid Phosphatase; chain A, domain 2) in Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform. Showing 1 copy in chain C.
SCOP SCOP annotations
56310
Class: Alpha and beta proteins (a+b)
Fold: Metallo-dependent phosphatases
Superfamily: Metallo-dependent phosphatases
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
The deposited structure of PDB entry 2nym contains 2 copies of SCOP domain 56310 (Protein serine/threonine phosphatase) in Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform. Showing 1 copy in chain C.
140819
Class: All alpha proteins
Fold: alpha-alpha superhelix
Superfamily: ARM repeat
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
The deposited structure of PDB entry 2nym contains 2 copies of SCOP domain 140819 (B56-like) in Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform. Showing 1 copy in chain B.
48385
Class: All alpha proteins
Fold: alpha-alpha superhelix
Superfamily: ARM repeat
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
The deposited structure of PDB entry 2nym contains 2 copies of SCOP domain 48385 (HEAT repeat) in Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. Showing 1 copy in chain A.

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