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HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T123C, T257S, V275C,S334A, S375W, Q428C, G431C) Complexed with CD4 and Antibody 17b

Source organisms:
Biochemical function: not assigned
Biological process: cell adhesion
Cellular component: membrane

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Ig-like domain-containing protein
  2. Ig-like domain-containing protein
The deposited structure of PDB entry 2ny6 contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain C.
The deposited structure of PDB entry 2ny6 contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain D.

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig-like domain-containing protein
  2. Ig-like domain-containing protein
The deposited structure of PDB entry 2ny6 contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain C.
The deposited structure of PDB entry 2ny6 contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain D.

PF05790
Domain description: Immunoglobulin C2-set domain
Occurring in:
  1. T-cell surface glycoprotein CD4
The deposited structure of PDB entry 2ny6 contains 1 copy of Pfam domain PF05790 (Immunoglobulin C2-set domain) in T-cell surface glycoprotein CD4. Showing 1 copy in chain B.

PF00047
Domain description: Immunoglobulin domain
Occurring in:
  1. T-cell surface glycoprotein CD4
The deposited structure of PDB entry 2ny6 contains 1 copy of Pfam domain PF00047 (Immunoglobulin domain) in T-cell surface glycoprotein CD4. Showing 1 copy in chain B.

PF00516
Domain description: Envelope glycoprotein GP120
Occurring in:
  1. Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein
The deposited structure of PDB entry 2ny6 contains 1 copy of Pfam domain PF00516 (Envelope glycoprotein GP120) in Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. T-cell surface glycoprotein CD4
  2. Ig-like domain-containing protein
  3. Ig-like domain-containing protein
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. T-cell surface glycoprotein CD4
  2. Ig-like domain-containing protein
  3. Ig-like domain-containing protein
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T-cell surface glycoprotein CD4
  2. Ig-like domain-containing protein
  3. Ig-like domain-containing protein
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. T-cell surface glycoprotein CD4
  2. Ig-like domain-containing protein
  3. Ig-like domain-containing protein
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. T-cell surface glycoprotein CD4
  2. Ig-like domain-containing protein
  3. Ig-like domain-containing protein
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Ig-like domain-containing protein
  2. Ig-like domain-containing protein
IPR000777
Domain description: Human immunodeficiency virus 1, envelope glycoprotein Gp120
Occurring in:
  1. Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Ig-like domain-containing protein
  2. Ig-like domain-containing protein
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR008424
Domain description: Immunoglobulin C2-set
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR013151
Domain description: Immunoglobulin
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR036377
Domain description: Gp120 core superfamily
Occurring in:
  1. Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. T-cell surface glycoprotein CD4
  2. Ig-like domain-containing protein
  3. Ig-like domain-containing protein
The deposited structure of PDB entry 2ny6 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T-cell surface glycoprotein CD4. Showing 2 copies in chain B.
The deposited structure of PDB entry 2ny6 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain C.
The deposited structure of PDB entry 2ny6 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain D.
2.170.40.20
Class: Mainly Beta
Architecture: Beta Complex
Topology: HIV Envelope Protein Gp120; Chain G
Homology: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
Occurring in:
  1. Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein
The deposited structure of PDB entry 2ny6 contains 1 copy of CATH domain 2.170.40.20 (HIV Envelope Protein Gp120; Chain G) in Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotations
48727
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. T-cell surface glycoprotein CD4
  2. Ig-like domain-containing protein
  3. Ig-like domain-containing protein
The deposited structure of PDB entry 2ny6 contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in T-cell surface glycoprotein CD4. Showing 1 copy in chain B.
The deposited structure of PDB entry 2ny6 contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain C.
The deposited structure of PDB entry 2ny6 contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain D.
48942
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. Ig-like domain-containing protein
  2. Ig-like domain-containing protein
The deposited structure of PDB entry 2ny6 contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain C.
The deposited structure of PDB entry 2ny6 contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain D.
49142
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. T-cell surface glycoprotein CD4
The deposited structure of PDB entry 2ny6 contains 1 copy of SCOP domain 49142 (C2 set domains) in T-cell surface glycoprotein CD4. Showing 1 copy in chain B.
56503
Class: Alpha and beta proteins (a+b)
Fold: gp120 core
Superfamily: gp120 core
Occurring in:
  1. Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein
The deposited structure of PDB entry 2ny6 contains 1 copy of SCOP domain 56503 (gp120 core) in Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein. Showing 1 copy in chain A.

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