PDBe 2nt2

X-ray diffraction
2.1Å resolution

Crystal Structure of Slingshot phosphatase 2

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of human slingshot phosphatase 2.
Proteins 68 408-12 (2007)
PMID: 17427953

Function and Biology Details

Reactions catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate. 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein phosphatase Slingshot homolog 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 145 amino acids
Theoretical weight: 17.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q76I76 (Residues: 305-448; Coverage: 10%)
  • Best match: Q76I76-4 (Residues: 305-449)
Gene names: KIAA1725, SSH2, SSH2L
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P32
Unit cell:
a: 94.58Å b: 94.58Å c: 38.77Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.144 0.142 0.174
Expression system: Escherichia coli