PDBe 2npq

X-ray diffraction
1.8Å resolution

A Novel Lipid Binding Site in the p38 alpha MAP Kinase

Released:
Source organism: Homo sapiens
Primary publication:
A novel lipid binding site formed by the MAP kinase insert in p38 alpha.
J. Mol. Biol. 375 70-9 (2008)
PMID: 17999933

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 42.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 68.607Å b: 74.212Å c: 74.571Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.245
Expression system: Escherichia coli