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Structure of the Protein Phosphatase 2A Holoenzyme

X-ray diffraction
3.3Å resolution
PDB entry 2npp coloured by chain, front view.
PDB entry 2npp coloured by chain, side view.
PDB entry 2npp coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 54649.83 Å2
Buried surface area: 8217.61 Å2
Dissociation area: 3,985.77 Å2
Dissociation energy (ΔGdiss): 8.26 kcal/mol
Dissociation entropy (TΔSdiss): 36.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151657
Assembly 2
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Multimeric state: hetero tetramer
Accessible surface area: 54742.57 Å2
Buried surface area: 8195.65 Å2
Dissociation area: 3,974.06 Å2
Dissociation energy (ΔGdiss): 6.59 kcal/mol
Dissociation entropy (TΔSdiss): 36.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151657

Macromolecules

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Chains: A, D
Length: 589 amino acids
Theoretical weight: 65.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30153 (Residues: 1-589; Coverage: 100%)
Gene name: PPP2R1A
Pfam: HEAT repeat
InterPro:
CATH: Leucine-rich Repeat Variant
SCOP: HEAT repeat
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 2npp, assembly 1, front view.
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 2npp, assembly 1, side view.
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 2npp, assembly 1, top view.
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Chains: B, E
Length: 449 amino acids
Theoretical weight: 52.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13362 (Residues: 1-442; Coverage: 84%)
Gene names: KIAA0044, PPP2R5C
Pfam: Protein phosphatase 2A regulatory B subunit (B56 family)
InterPro:
CATH: Leucine-rich Repeat Variant
SCOP: B56-like
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform in PDB entry 2npp, assembly 1, front view.
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform in PDB entry 2npp, assembly 1, side view.
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform in PDB entry 2npp, assembly 1, top view.
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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Chains: C, F
Length: 309 amino acids
Theoretical weight: 35.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P67775 (Residues: 1-309; Coverage: 100%)
Gene name: PPP2CA
Pfam: Calcineurin-like phosphoesterase
InterPro:
CATH: Purple Acid Phosphatase; chain A, domain 2
SCOP: Protein serine/threonine phosphatase
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 2npp, assembly 1, front view.
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 2npp, assembly 1, side view.
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 2npp, assembly 1, top view.
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microcystin LR
Chains: X, Y
Length: 7 amino acids
Theoretical weight: 1.01 KDa
Source organism: Cyanobacteriota
Expression system: Not provided
microcystin LR in PDB entry 2npp, assembly 1, front view.
microcystin LR in PDB entry 2npp, assembly 1, side view.
microcystin LR in PDB entry 2npp, assembly 1, top view.
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