PDBe 2nnv

X-ray diffraction
1.1Å resolution

Structure of inhibitor binding to Carbonic Anhydrase II


Function and Biology Details

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P00918 (Residues: 2-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2, null
Spacegroup: P21
Unit cell:
a: 42.365Å b: 41.213Å c: 72.145Å
α: 90° β: 104.83° γ: 90°
R R work R free
0.133 not available 0.164
Expression system: Escherichia coli BL21(DE3)