PDBe 2nna

X-ray diffraction
2.1Å resolution

Structure of the MHC class II molecule HLA-DQ8 bound with a deamidated gluten peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Alpha/beta-gliadin MM1 Chain: C
Molecule details ›
Chain: C
Length: 18 amino acids
Theoretical weight: 2.01 KDa
Source organism: Triticum aestivum
Expression system: Not provided
UniProt:
  • Canonical: P18573 (Residues: 243-260; Coverage: 6%)
HLA class II histocompatibility antigen, DQ alpha 1 chain Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 21.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01909 (Residues: 24-78, 79-206; Coverage: 79%)
Gene name: HLA-DQA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DQ beta 1 chain Chain: B
Molecule details ›
Chain: B
Length: 207 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01920 (Residues: 33-224; Coverage: 84%)
Gene names: HLA-DQB, HLA-DQB1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 58.83Å b: 92.52Å c: 113.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.248
Expression systems:
  • Not provided
  • Spodoptera frugiperda