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STIL binding to the Polo-box domain 3 of PLK4 regulates centriole duplication

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.11.21: Polo kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (spindle-pole-dependent)
Alternative Name(s):
  • Cdc5
  • Cdc5p
  • PLK
  • POLO kinase
  • Plk
  • Plk1
  • Plo1
  • Polo serine-threonine kinase
  • Polo-like kinase
  • Polo-like kinase 1
  • STK21
  • Serine/threonine-specific Drosophila kinase polo

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR000959
Domain description: POLO box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK4
IPR033696
Domain description: Plk4, C-terminal polo-box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK4

Structure domain

CATH CATH domain
3.30.1120.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Arylsulfatase, C-terminal domain
Homology: POLO box domain
Occurring in:
  1. Serine/threonine-protein kinase PLK4
The deposited structure of PDB entry 2n19 contains 1 copy of CATH domain 3.30.1120.30 (Arylsulfatase, C-terminal domain) in Serine/threonine-protein kinase PLK4. Showing 1 copy in chain A.

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