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Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: apoptotic process
Cellular component: nucleus

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00870
Domain description: P53 DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 2mej contains 1 copy of Pfam domain PF00870 (P53 DNA-binding domain) in Cellular tumor antigen p53. Showing 1 copy in chain B.

PF00452
Domain description: Apoptosis regulator proteins, Bcl-2 family
Occurring in:
  1. Bcl-2-like protein 1
The deposited structure of PDB entry 2mej contains 1 copy of Pfam domain PF00452 (Apoptosis regulator proteins, Bcl-2 family) in Bcl-2-like protein 1. Showing 1 copy in chain A.

PF02180
Domain description: Bcl-2 homology region 4
Occurring in:
  1. Bcl-2-like protein 1
The deposited structure of PDB entry 2mej contains 1 copy of Pfam domain PF02180 (Bcl-2 homology region 4) in Bcl-2-like protein 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002117
Domain description: p53 tumour suppressor family
Occurring in:
  1. Cellular tumor antigen p53
IPR026298
Domain description: Bcl-2 family
Occurring in:
  1. Bcl-2-like protein 1
IPR013279
Domain description: Apoptosis regulator, Bcl-X
Occurring in:
  1. Bcl-2-like protein 1
IPR003093
Domain description: Apoptosis regulator, Bcl-2 protein, BH4
Occurring in:
  1. Bcl-2-like protein 1
IPR011615
Domain description: p53, DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
IPR036834
Domain description: Bcl-2-like superfamily
Occurring in:
  1. Bcl-2-like protein 1
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53
IPR012346
Domain description: p53/RUNT-type transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53
IPR020726
Domain description: Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Occurring in:
  1. Bcl-2-like protein 1
IPR020717
Domain description: Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Occurring in:
  1. Bcl-2-like protein 1
IPR046371
Domain description: Bcl-2, Bcl-2 homology region 1-3
Occurring in:
  1. Bcl-2-like protein 1
IPR002475
Domain description: Bcl2-like
Occurring in:
  1. Bcl-2-like protein 1
IPR020728
Domain description: Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Occurring in:
  1. Bcl-2-like protein 1
IPR020731
Domain description: Apoptosis regulator, Bcl-2, BH4 motif, conserved site
Occurring in:
  1. Bcl-2-like protein 1
IPR004725
Domain description: Apoptosis regulator, Bcl-2/ BclX
Occurring in:
  1. Bcl-2-like protein 1

Structure domains

CATH CATH domains
2.60.40.720
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 2mej contains 1 copy of CATH domain 2.60.40.720 (Immunoglobulin-like) in Cellular tumor antigen p53. Showing 1 copy in chain B.
1.10.437.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Apoptosis Regulator Bcl-x
Homology: Blc2-like
Occurring in:
  1. Bcl-2-like protein 1
The deposited structure of PDB entry 2mej contains 1 copy of CATH domain 1.10.437.10 (Apoptosis Regulator Bcl-x) in Bcl-2-like protein 1. Showing 1 copy in chain A.

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