› 2mah

Solution NMR

Solution structure of Smoothened

Released:
DOI: 10.2210/pdb2mah/pdb
PDB entry 2mah coloured by chain, ensemble of 20 models, front view.
PDB entry 2mah coloured by chain, ensemble of 20 models, side view.
PDB entry 2mah coloured by chain, ensemble of 20 models, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.
Rana R, Carroll CE, Lee HJ, Bao J, Marada S, Grace CR, Guibao CD, Ogden SK, Zheng JJ
Nat Commun 4 2965 (2013)
PMID: 24351982

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161046 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein smoothened Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.88 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: P91682 (Residues: 85-202; Coverage: 12%)
Gene names: CG11561, smo
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

24 review citations

The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda et al. (2018)
23 more

5 mentions without citation

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Huang et al. (2016)
4 more