› 2m5v

Solution NMR

Three-dimensional structure of human NLRP10/PYNOD pyrin domain

Released:
DOI: 10.2210/pdb2m5v/pdb
PDB entry 2m5v coloured by chain, ensemble of 20 models, front view.
PDB entry 2m5v coloured by chain, ensemble of 20 models, side view.
PDB entry 2m5v coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue.
Su MY, Kuo CI, Chang CF, Chang CI
PLoS One 8 e67843 (2013)
PMID: 23861819

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 10 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 11.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86W26 (Residues: 1-100; Coverage: 15%)
Gene names: NALP10, NLRP10, NOD8, PYNOD
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes.
Sharma et al. (2021)
6 more

9 mentions without citation

Emerging significance of NLRs in inflammatory bowel disease.
Davis et al. (2014)
8 more