PDBe 2lvg

Solution NMR

NMR structure of HCV Non-structural protein AB, NS4B(1-40)


Function and Biology Details

Reactions catalysed:
ATP + H(2)O = ADP + phosphate. 
NTP + H(2)O = NDP + phosphate. 
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'. 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Non-structural protein 4B Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.39 KDa
Source organism: Hepatitis C virus JFH-1
Expression system: Not provided
  • Canonical: Q99IB8 (Residues: 1716-1755; Coverage: 1%)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 75%
Refinement method: torsion angle dynamics
Chemical shifts: BMR18568  
Expression system: Not provided