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PDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)

Solution NMR
PDB entry 2lob coloured by chain, ensemble of 7 models, front view.
PDB entry 2lob coloured by chain, ensemble of 7 models, side view.
PDB entry 2lob coloured by chain, ensemble of 7 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Golgi-associated PDZ and coiled-coil motif-containing protein and Cystic fibrosis transmembrane conductance regulator
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Multimeric state: hetero dimer
Accessible surface area: 5467.51 Å2
Buried surface area: 1030.78 Å2
Dissociation area: 515.39 Å2
Dissociation energy (ΔGdiss): 1.13 kcal/mol
Dissociation entropy (TΔSdiss): 7.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146652

Macromolecules

Golgi-associated PDZ and coiled-coil motif-containing protein
Chain: A
Length: 112 amino acids
Theoretical weight: 12.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HD26 (Residues: 286-370; Coverage: 18%)
Gene names: CAL, FIG, GOPC
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
Golgi-associated PDZ and coiled-coil motif-containing protein in PDB entry 2lob, assembly 1, front view.
Golgi-associated PDZ and coiled-coil motif-containing protein in PDB entry 2lob, assembly 1, side view.
Golgi-associated PDZ and coiled-coil motif-containing protein in PDB entry 2lob, assembly 1, top view.
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Cystic fibrosis transmembrane conductance regulator
Chain: B
Length: 8 amino acids
Theoretical weight: 990 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13569 (Residues: 1473-1480; Coverage: 1%)
Gene names: ABCC7, CFTR
Cystic fibrosis transmembrane conductance regulator in PDB entry 2lob, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 2lob, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 2lob, assembly 1, top view.
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