› 2l4q

Solution NMR

Solution Structures of Oxidized and Reduced Thioredoxin C from M. tb

Released:
DOI: 10.2210/pdb2l4q/pdb
PDB entry 2l4q coloured by chain, ensemble of 20 models, front view.
PDB entry 2l4q coloured by chain, ensemble of 20 models, side view.
PDB entry 2l4q coloured by chain, ensemble of 20 models, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design.
Olson AL, Neumann TS, Cai S, Sem DS
Proteins 81 675-89 (2013)
PMID: 23229911

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 12.56 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WG67 (Residues: 1-116; Coverage: 100%)
Gene names: MTV028.05, Rv3914, trx, trxA, trxC
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

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Citations

4 citation in other articles

Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus.
Sweeney et al. (2017)
3 more

6 mentions without citation

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.
Kim et al. (2017)
5 more