PDBe 2kso

Solution NMR

EphA2:SHIP2 SAM:SAM complex

Released:
Source organism: Homo sapiens
Entry authors: Hota PK, Preeti C, Stetzik L, Kim S, Wang B, Lee H, Buck M

Function and Biology Details

Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29317 (Residues: 908-972; Coverage: 7%)
Gene names: ECK, EPHA2
Structure domains: Transcription Factor, Ets-1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Chain: B
Molecule details ›
Chain: B
Length: 76 amino acids
Theoretical weight: 8.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15357 (Residues: 1200-1258; Coverage: 5%)
Gene names: INPPL1, SHIP2
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli