› 2kqt

Solid-state NMR

Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine

Released:
DOI: 10.2210/pdb2kqt/pdb
PDB entry 2kqt coloured by chain, ensemble of 17 models, front view.
PDB entry 2kqt coloured by chain, ensemble of 17 models, side view.
PDB entry 2kqt coloured by chain, ensemble of 17 models, top view.
Source organism: Influenza A virus H3N2
Primary publication:
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers.
Cady SD, Schmidt-Rohr K, Wang J, Soto CS, Degrado WF, Hong M
Nature 463 689-92 (2010)
PMID: 20130653

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 25 amino acids
Theoretical weight: 2.73 KDa
Source organism: Influenza A virus H3N2
Expression system: Not provided
UniProt:
  • Canonical: O70632 (Residues: 22-46; Coverage: 26%)
Gene name: M

Ligands and Environments

1 bound ligand:
Ligand 308 1 x 308
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 10%
Refinement method: simulated annealing, Monte Carlo
Expression system: Not provided

Quick links

Citations

66 review citations

Viroporins: structure and biological functions.
Nieva et al. (2012)
65 more

48 mentions without citation

Membrane protein structure and dynamics from NMR spectroscopy.
Hong et al. (2012)
47 more