PDBe 2kk6

Solution NMR

Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d

Released:
Source organism: Homo sapiens
Entry authors: Tang Y, Wang D, Nwosu C, Owens L, Xiao R, Liu J, Baran MC, Swapna G, Acton TB, Rost B, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fer Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16591 (Residues: 453-557; Coverage: 13%)
Gene names: FER, TYK3
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing, molecular dynamics
Chemical shifts: BMR16353  
Expression system: Escherichia coli