PDBe 2kaw

Solution NMR

NMR structure of the mDvl1 PDZ domain in complex with its inhibitor

Source organism: Mus musculus
Primary publication:
Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.
Angew. Chem. Int. Ed. Engl. 48 6448-52 (2009)
PMID: 19637179

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Segment polarity protein dishevelled homolog DVL-1 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P51141 (Residues: 248-337; Coverage: 13%)
Gene names: Dvl, Dvl1
Sequence domains: PDZ domain (Also known as DHR or GLGF)
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, HADDOCK
Expression system: Escherichia coli