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THE CRYSTAL STRUCTURE OF UREASE FROM KLEBSIELLA AEROGENES AT 2.2 ANGSTROMS RESOLUTION

Source organism: Klebsiella aerogenes
Biochemical function: hydrolase activity
Biological process: urea catabolic process
Cellular component: cytoplasm

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EC 3.5.1.5: Urease

Reaction catalysed:
Urea + H(2)O = CO(2) + 2 NH(3)
Systematic name:
Urea amidohydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01979
Domain description: Amidohydrolase family
Occurring in:
  1. Urease subunit alpha
The deposited structure of PDB entry 2kau contains 1 copy of Pfam domain PF01979 (Amidohydrolase family) in Urease subunit alpha. Showing 1 copy in chain C.

PF00449
Domain description: Urease alpha-subunit, N-terminal domain
Occurring in:
  1. Urease subunit alpha
The deposited structure of PDB entry 2kau contains 1 copy of Pfam domain PF00449 (Urease alpha-subunit, N-terminal domain) in Urease subunit alpha. Showing 1 copy in chain C.

PF00699
Domain description: Urease beta subunit
Occurring in:
  1. Urease subunit beta
The deposited structure of PDB entry 2kau contains 1 copy of Pfam domain PF00699 (Urease beta subunit) in Urease subunit beta. Showing 1 copy in chain B.

PF00547
Domain description: Urease, gamma subunit
Occurring in:
  1. Urease subunit gamma
The deposited structure of PDB entry 2kau contains 1 copy of Pfam domain PF00547 (Urease, gamma subunit) in Urease subunit gamma. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005848
Domain description: Urease, alpha subunit
Occurring in:
  1. Urease subunit alpha
IPR011059
Domain description: Metal-dependent hydrolase, composite domain superfamily
Occurring in:
  1. Urease subunit alpha
IPR036461
Domain description: Urease, beta subunit superfamily
Occurring in:
  1. Urease subunit beta
IPR002019
Domain description: Urease, beta subunit-like
Occurring in:
  1. Urease subunit beta
IPR036463
Domain description: Urease, gamma subunit superfamily
Occurring in:
  1. Urease subunit gamma
IPR002026
Domain description: Urease, gamma/gamma-beta subunit
Occurring in:
  1. Urease subunit gamma
IPR017950
Domain description: Urease active site
Occurring in:
  1. Urease subunit alpha
IPR032466
Domain description: Metal-dependent hydrolase
Occurring in:
  1. Urease subunit alpha
IPR017951
Domain description: Urease alpha subunit, C-terminal
Occurring in:
  1. Urease subunit alpha
IPR029754
Domain description: Urease nickel binding site
Occurring in:
  1. Urease subunit alpha
IPR006680
Domain description: Amidohydrolase-related
Occurring in:
  1. Urease subunit alpha
IPR011612
Domain description: Urease alpha-subunit, N-terminal domain
Occurring in:
  1. Urease subunit alpha
IPR012010
Domain description: Urease, gamma subunit
Occurring in:
  1. Urease subunit gamma

Structure domains

CATH CATH domains
3.20.20.140
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Metal-dependent hydrolases
Occurring in:
  1. Urease subunit alpha
The deposited structure of PDB entry 2kau contains 1 copy of CATH domain 3.20.20.140 (TIM Barrel) in Urease subunit alpha. Showing 1 copy in chain C.
2.30.40.10
Class: Mainly Beta
Architecture: Roll
Topology: Urease, subunit C; domain 1
Homology: Urease, subunit C, domain 1
Occurring in:
  1. Urease subunit alpha
The deposited structure of PDB entry 2kau contains 1 copy of CATH domain 2.30.40.10 (Urease, subunit C; domain 1) in Urease subunit alpha. Showing 1 copy in chain C.
2.10.150.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Urease, subunit B
Homology: Urease, beta subunit
Occurring in:
  1. Urease subunit beta
The deposited structure of PDB entry 2kau contains 1 copy of CATH domain 2.10.150.10 (Urease, subunit B) in Urease subunit beta. Showing 1 copy in chain B.
3.30.280.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Urease; subunit A
Homology: Urease, gamma-like subunit
Occurring in:
  1. Urease subunit gamma
The deposited structure of PDB entry 2kau contains 1 copy of CATH domain 3.30.280.10 (Urease; subunit A) in Urease subunit gamma. Showing 1 copy in chain A.
SCOP SCOP annotations
51560
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Occurring in:
  1. Urease subunit alpha
The deposited structure of PDB entry 2kau contains 1 copy of SCOP domain 51560 (alpha-subunit of urease, catalytic domain) in Urease subunit alpha. Showing 1 copy in chain C.
51339
Class: All beta proteins
Fold: Composite domain of metallo-dependent hydrolases
Superfamily: Composite domain of metallo-dependent hydrolases
Occurring in:
  1. Urease subunit alpha
The deposited structure of PDB entry 2kau contains 1 copy of SCOP domain 51339 (alpha-Subunit of urease) in Urease subunit alpha. Showing 1 copy in chain C.
51279
Class: All beta proteins
Fold: beta-clip
Superfamily: Urease, beta-subunit
Occurring in:
  1. Urease subunit beta
The deposited structure of PDB entry 2kau contains 1 copy of SCOP domain 51279 (Urease, beta-subunit) in Urease subunit beta. Showing 1 copy in chain B.
54112
Class: Alpha and beta proteins (a+b)
Fold: Urease, gamma-subunit
Superfamily: Urease, gamma-subunit
Occurring in:
  1. Urease subunit gamma
The deposited structure of PDB entry 2kau contains 1 copy of SCOP domain 54112 (Urease, gamma-subunit) in Urease subunit gamma. Showing 1 copy in chain A.

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