PDBe 2k9u

Solution NMR

Solution NMR structure of the Filamin-migfilin complex

Released:
Source organism: Homo sapiens
Primary publication:
Migfilin, a molecular switch in regulation of integrin activation.
J. Biol. Chem. 284 4713-22 (2009)
PMID: 19074766

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Filamin-C Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14315 (Residues: 2302-2415; Coverage: 4%)
Gene names: ABPL, FLN2, FLNC
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins
Filamin-binding LIM protein 1 Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8WUP2 (Residues: 1-24; Coverage: 6%)
Gene names: FBLIM1, FBLP1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: simulated annealing
Chemical shifts: BMR16002  
Expression systems:
  • Escherichia coli
  • Not provided