PDBe 2jld

X-ray diffraction
2.35Å resolution

Extremely Tight Binding of Ruthenium Complex to Glycogen Synthase Kinase 3

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero trimer
monomeric
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 420 amino acids
Theoretical weight: 46.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49841 (Residues: 1-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:
PEPTIDE (ALA-GLY-GLY-ALA-ALA-ALA-ALA-ALA) Chain: E
Molecule details ›
Chain: E
Length: 8 amino acids
Theoretical weight: 559 Da
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 83.041Å b: 86.114Å c: 177.398Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.227
Expression systems:
  • Escherichia coli
  • Not provided