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AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE

Source organisms:
Biochemical function: clathrin adaptor activity
Biological process: vesicle-mediated transport
Cellular component: membrane coat

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01217
Domain description: Clathrin adaptor complex small chain
Occurring in:
  1. AP-2 complex subunit sigma
  2. AP-2 complex subunit mu
The deposited structure of PDB entry 2jkr contains 2 copies of Pfam domain PF01217 (Clathrin adaptor complex small chain) in AP-2 complex subunit sigma. Showing 1 copy in chain D [auth I].
The deposited structure of PDB entry 2jkr contains 2 copies of Pfam domain PF01217 (Clathrin adaptor complex small chain) in AP-2 complex subunit mu. Showing 1 copy in chain F [auth M].

PF01602
Domain description: Adaptin N terminal region
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
The deposited structure of PDB entry 2jkr contains 2 copies of Pfam domain PF01602 (Adaptin N terminal region) in AP-2 complex subunit alpha-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 2jkr contains 2 copies of Pfam domain PF01602 (Adaptin N terminal region) in AP-2 complex subunit beta. Showing 1 copy in chain B.

PF12104
Domain description: T cell CD4 receptor C terminal region
Occurring in:
  1. T-cell surface glycoprotein CD4
The deposited structure of PDB entry 2jkr contains 2 copies of Pfam domain PF12104 (T cell CD4 receptor C terminal region) in T-cell surface glycoprotein CD4. Showing 1 copy in chain G [auth P].

PF00928
Domain description: Adaptor complexes medium subunit family
Occurring in:
  1. AP-2 complex subunit mu
The deposited structure of PDB entry 2jkr contains 2 copies of Pfam domain PF00928 (Adaptor complexes medium subunit family) in AP-2 complex subunit mu. Showing 1 copy in chain F [auth M].

InterPro InterPro annotations
IPR001392
Domain description: Clathrin adaptor, mu subunit
Occurring in:
  1. AP-2 complex subunit mu
IPR028565
Domain description: Mu homology domain
Occurring in:
  1. AP-2 complex subunit mu
IPR018240
Domain description: Clathrin adaptor, mu subunit, conserved site
Occurring in:
  1. AP-2 complex subunit mu
IPR022775
Domain description: AP complex, mu/sigma subunit
Occurring in:
  1. AP-2 complex subunit sigma
  2. AP-2 complex subunit mu
IPR016635
Domain description: Adaptor protein complex, sigma subunit
Occurring in:
  1. AP-2 complex subunit sigma
IPR011012
Domain description: Longin-like domain superfamily
Occurring in:
  1. AP-2 complex subunit sigma
  2. AP-2 complex subunit mu
IPR000225
Domain description: Armadillo
Occurring in:
  1. AP-2 complex subunit beta
IPR002553
Domain description: Clathrin/coatomer adaptor, adaptin-like, N-terminal
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
IPR043512
Domain description: Mu2, C-terminal domain
Occurring in:
  1. AP-2 complex subunit mu
IPR036168
Domain description: AP-2 complex subunit mu, C-terminal superfamily
Occurring in:
  1. AP-2 complex subunit mu
IPR043532
Domain description: AP-2 complex subunit mu, N-terminal
Occurring in:
  1. AP-2 complex subunit mu
IPR000804
Domain description: Clathrin adaptor complex, small chain
Occurring in:
  1. AP-2 complex subunit sigma
IPR027156
Domain description: AP-2 complex subunit sigma
Occurring in:
  1. AP-2 complex subunit sigma
IPR026739
Domain description: AP complex subunit beta
Occurring in:
  1. AP-2 complex subunit beta
IPR016342
Domain description: AP-1/2/4 complex subunit beta
Occurring in:
  1. AP-2 complex subunit beta
IPR017107
Domain description: Adaptor protein complex AP-1, gamma subunit
Occurring in:
  1. AP-2 complex subunit alpha-2

Structure domains

CATH CATH domains
2.60.40.1170
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Mu homology domain, subdomain B
Occurring in:
  1. AP-2 complex subunit mu
The deposited structure of PDB entry 2jkr contains 4 copies of CATH domain 2.60.40.1170 (Immunoglobulin-like) in AP-2 complex subunit mu. Showing 2 copies in chain F [auth M].
3.30.450.60
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Beta-Lactamase
Occurring in:
  1. AP-2 complex subunit sigma
  2. AP-2 complex subunit mu
The deposited structure of PDB entry 2jkr contains 2 copies of CATH domain 3.30.450.60 (Beta-Lactamase) in AP-2 complex subunit sigma. Showing 1 copy in chain D [auth I].
The deposited structure of PDB entry 2jkr contains 2 copies of CATH domain 3.30.450.60 (Beta-Lactamase) in AP-2 complex subunit mu. Showing 1 copy in chain F [auth M].
1.25.10.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Leucine-rich Repeat Variant
Homology: Leucine-rich Repeat Variant
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
The deposited structure of PDB entry 2jkr contains 2 copies of CATH domain 1.25.10.10 (Leucine-rich Repeat Variant) in AP-2 complex subunit alpha-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 2jkr contains 2 copies of CATH domain 1.25.10.10 (Leucine-rich Repeat Variant) in AP-2 complex subunit beta. Showing 1 copy in chain B.

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