PDBe 2jgz

X-ray diffraction
2.9Å resolution

Crystal structure of phospho-CDK2 in complex with Cyclin B

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G2/mitotic-specific cyclin-B1 Chain: B
Molecule details ›
Chain: B
Length: 260 amino acids
Theoretical weight: 30.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14635 (Residues: 167-426; Coverage: 60%)
Gene names: CCNB, CCNB1
Sequence domains:
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-288; Coverage: 97%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P6122
Unit cell:
a: 104.78Å b: 104.78Å c: 251.635Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.205 0.275
Expression system: Escherichia coli