PDBe 2jfm

X-ray diffraction
2.85Å resolution

CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
STE20-like serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 37.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H2G2 (Residues: 12-15, 16-320; Coverage: 25%)
Gene names: KIAA0204, SLK, STK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6122
Unit cell:
a: 102.073Å b: 102.073Å c: 176.993Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.23 0.271
Expression system: Escherichia coli BL21(DE3)