PDBe 2jf9

X-ray diffraction
2.1Å resolution

ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-SPECIFIC PEPTIDE ANTAGONIST

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 12-mer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AB5 PEPTIDE Chains: P, Q, R
Molecule details ›
Chains: P, Q, R
Length: 13 amino acids
Theoretical weight: 1.54 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
Estrogen receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 252 amino acids
Theoretical weight: 28.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 303-533; Coverage: 39%)
  • Best match: P03372-2 (Residues: 254-421)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P3221
Unit cell:
a: 193.707Å b: 193.707Å c: 64.441Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.18 0.198
Expression systems:
  • Not provided
  • Escherichia coli