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STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654

X-ray diffraction
2.3Å resolution
PDB entry 2jdr coloured by chain, front view.
PDB entry 2jdr coloured by chain, side view.
PDB entry 2jdr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RAC-beta serine/threonine-protein kinase and Glycogen synthase kinase-3 beta
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Multimeric state: hetero dimer
Accessible surface area: 15004.83 Å2
Buried surface area: 2311.28 Å2
Dissociation area: 729.93 Å2
Dissociation energy (ΔGdiss): -0.05 kcal/mol
Dissociation entropy (TΔSdiss): 7.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152088

Macromolecules

RAC-beta serine/threonine-protein kinase
Chain: A
Length: 342 amino acids
Theoretical weight: 39.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31751 (Residues: 146-469, 470-477; Coverage: 69%)
Gene name: AKT2
Pfam:
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
RAC-beta serine/threonine-protein kinase in PDB entry 2jdr, assembly 1, front view.
RAC-beta serine/threonine-protein kinase in PDB entry 2jdr, assembly 1, side view.
RAC-beta serine/threonine-protein kinase in PDB entry 2jdr, assembly 1, top view.
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Glycogen synthase kinase-3 beta
Chain: C
Length: 10 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49841 (Residues: 3-12; Coverage: 2%)
Gene name: GSK3B
Glycogen synthase kinase-3 beta in PDB entry 2jdr, assembly 1, front view.
Glycogen synthase kinase-3 beta in PDB entry 2jdr, assembly 1, side view.
Glycogen synthase kinase-3 beta in PDB entry 2jdr, assembly 1, top view.
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