PDBe 2jc6

X-ray diffraction
2.3Å resolution

Crystal structure of human calmodulin-dependent protein kinase 1D

Released:
Source organism: Homo sapiens
Entry authors: Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Bhatia C, Shrestha L, Salah E, Smee C, Colebrook S, Berridge G, Gileadi O, Bunkoczi G, Ugochukwu E, Pike ACW, von Delft F, Knapp S, Sundstrom M, Weigelt J, Arrowsmith CH, Edwards A

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type 1D Chains: A, C
Molecule details ›
Chains: A, C
Length: 334 amino acids
Theoretical weight: 37.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IU85 (Residues: 1-333; Coverage: 87%)
Gene names: CAMK1D, CAMKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 39.64Å b: 93.06Å c: 101.86Å
α: 90° β: 96.16° γ: 90°
R-values:
R R work R free
0.189 0.186 0.248
Expression system: Escherichia coli BL21(DE3)