Structure analysis

N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG) BOUND TO CBL-B PEPTIDE

X-ray diffraction
1.7Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 4400 Å2
Buried surface area: 950 Å2
Dissociation area: 450 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -2 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 62 amino acids
Theoretical weight: 7.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5K6 (Residues: 1-62; Coverage: 10%)
Gene name: CD2AP
Pfam: Variant SH3 domain
InterPro:
CATH: SH3 Domains

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Chain: C
Length: 11 amino acids
Theoretical weight: 1.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13191 (Residues: 902-912; Coverage: 1%)
Gene names: CBLB, Nbla00127, RNF56

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